addicted2wheels

A blog about bikes, bike racing and physiological research.

Thursday, February 07, 2008

More on the dope that dopes dope with...

From Dopage du Jour:
  • erythropoiesis is essentially the production of red blood cells, and the more you have of those babies the better your oxygen transport capacity
  • erythropoietin or EPO is the substance that triggers production of red blood cells - the more EPO you have the more red blood cells are triggered to mature in the bone marrow
  • EPO production is normally in your kidneys but lately pharmaceutical companies have built factories to make it as well, for medicinal reasons only, of course
  • Thyroid hormones, thyroid-stimulating hormone, adrenal cortical steroids (like glucocorticosteroids or Prednisone) , adrenocorticotrophic hormone, and human growth hormone (HGH) all promote erythropoietin formation, which again means more red blood cells in your blood; however before you all rush off to secure illegal supplies of banned substances let's note that the side-effects of these substances on otherwise healthy people will vary from catastrophic to dangerous, and in fact...
  • Very high doses of steroid hormones (whatever that means - 50-60mg/day, perhaps of a cortico-steroid?) "seem" to inhibit erythropoiesis, which is to say lower your red cell production and release - and is thus not very good for your bike riding, is it?

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